Engineered protein cages for selective heparin encapsulation

Välimäki, Salla; Liu, Qing; Schoonen, Lise; F. M. Vervoort, Daan; Nonappa, Nonappa; Linko, Veikko; Nolte, Roeland J. M.; C. M. van Hest, Jan; Kostiainen, Mauri

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Engineered protein cages for selective heparin encapsulation

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Title:	Engineered protein cages for selective heparin encapsulation
Author(s):	Välimäki, Salla ; Liu, Qing ; Schoonen, Lise ; F. M. Vervoort, Daan ; Nonappa, Nonappa ; Linko, Veikko ; Nolte, Roeland J. M. ; C. M. van Hest, Jan ; Kostiainen, Mauri
Date:	2021-02-07
Language:	en
Pages:	5 1272-1276
Department:	Biohybrid Materials Radboud University Eindhoven University of Technology Department of Applied Physics Department of Bioproducts and Biosystems
Series:	Journal of Materials Chemistry B, Volume 9, issue 5
ISSN:	2050-750X
DOI-number:	10.1039/D0TB02541K
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This publication is imported from Aalto University Research information portal: https://research.aalto.fi > View this publication in Research information portal > View/Open full text file from Research information portal
Citation: Välimäki , S , Liu , Q , Schoonen , L , F. M. Vervoort , D , Nonappa , N , Linko , V , Nolte , R J M , C. M. van Hest , J & Kostiainen , M 2021 , ' Engineered protein cages for selective heparin encapsulation ' , Journal of Materials Chemistry B , vol. 9 , no. 5 , pp. 1272-1276 . https://doi.org/10.1039/D0TB02541K
Abstract: A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

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