Hajos-Parrish ketone: approaches toward C-ring prcursors of 7-deoxytaxol

Altmetrics



Title:	Hajos-Parrish ketone: approaches toward C-ring prcursors of 7-deoxytaxol
Author(s):	Lajunen, M. ; Koskinen, A.
Date:	2000
Language:	en
Pages:	1439-1443
Department:	Department of Chemistry
Series:	Journal Chem. Soc., Perkin Trans., issue 1
DOI-number:	10.1039/a909471g
Keywords:	synthesis, taxol
» Show full item record
This publication is imported from Aalto University Research information portal: https://research.aalto.fi > View this publication in Research information portal > View/Open full text file from Research information portal
Citation: Lajunen , M & Koskinen , A 2000 , ' Hajos-Parrish ketone: approaches toward C-ring prcursors of 7-deoxytaxol ' , Journal of the Chemical Society, Perkin Transactions 1 , no. 1 , pp. 1439-1443 . https://doi.org/10.1039/a909471g
Abstract: Two routes were evaluated for the preparation of multiply functionalized cyclohexane derivatives in a stereocontrolled fashion from readily available Hajos–Parrish ketone 1. Reduction (catalytic or dissolving metal) led to the cis-isomer 8, in stark contrast to previous literature. Finally, modification of earlier steroid chemistry allowed the synthesis of the trans-isomer 14. The latter is a useful intermediate for the synthesis of 7-deoxytaxol derivatives.

Permanent link to this item: http://urn.fi/URN:NBN:fi:aalto-201609234325 Email this Export to RefWorks QR Code Print BibTex Tweet